Dr. Diego Peñadiego2017

    Professor in Organic Chemistry

    Centro Singular de Investigación en Química Biolóxica

    e Materiais Moleculares (CIQUS)

    Universidade de Santiago de Compostela

    15782-Santiago de Compostela, Spain




Researcher ID: D-2051-2009

ORCID: 0000-0003-3814-589X


Diego Peña Gil was born in Santiago de Compostela in 1974. He obtained his PhD degree in 2001 from the University of Santiago de Compostela, under supervision of D. Pérez and E. Guitián. He was PhD visitor at Harvard University (1999, Jacobsen group), LMU Munich (2000, Knochel group) and UAM Madrid (2001, Echavarren group). During 2002 and 2003 he joined the group of B. L. Feringa (Nobel Laureate 2016, Groningen University, The Netherlands) as a Marie Curie Post-Doctoral Fellow. He was visiting researcher at DSM Research (Geleen, The Netherlands) and CRANN, Trinity College (Dublin, Ireland). In 2004 he obtained a Ramón y Cajal research position. In 2008 he got an Associate Professor position and in 2020 Full Professor at the University of Santiago de Compostela. In 2018 he was awarded with the Ignacio Ribas Medal by the Specialized Group on Organic Chemistry of the Spanish Royal Society of Chemistry (RSEQ). In 2020 he was awarded with an ERC Synergy Grant (MolDAM), jointly with Leo Gross (IBM Research Zurich) and Jascha Repp (Universität Regensburg). In 2023 he was honored with the Research Excellence Award from RSEQ.








Dr. Peña research interests are focused on the discovery of new synthetic methodologies, the synthesis of large aromatic compounds and nanographenes, and the development of on-surface chemistry.


130 publications, >7000 times cited, h-index: 43 (Sept 2023, WoS)


For papers after 2020, see: scholar.google.com/citations


103. Intramolecular coupling of terminal alkynes by atom manipulation

F. Albrecht,* D. Rey, S. Fatayer, D. Pérez, D. Peña,* L. Gross*

Angew. Chem. Int. Ed. 2020, 59, 22989    DOI: 10.1002/anie.202009200











102. 2,6,10-Triphenylenotriyne: a star-shaped trisaryne

I. Pozo, D. Peña, E. Guitián, D. Pérez*

Chem. Commun. 2020, 56, 12853   DOI: 10.1039/D0CC05686C


 101. Chemically synthesized chevron-like graphene nanoribbons for electrochemical sensors development: determination of epinephrine

R. Sainz, M. Pozo, M. Vilas-Varela, J. Castro-Esteban, M. Pérez Corral, L. Vázquez, E. Blanco, D. Peña, J. A. Martín-Gago, G. J. Ellis, M. D. Petit-Domínguez, C. Quintana, E. Casero*

Sci. Rep. 2020, 10:14614  DOI: 10.1038/s41598-020-71554-1






 100. Stabilizing Edge-Fluorination in Graphene Nanoribbons

M. Panighel,* S. Quiroga, P. Brandimarte, C. Moreno, A. Garcia-Lekue, M. Vilas-Varela, D. Rey, G. Sauthier, G. Ceballos, D. Peña,* A. Mugarza*

ACS Nano 2020, 14, 11120  DOI: 10.1021/acsnano.0c01837












 99. Magnetism of topological boundary states induced by boron substitution in graphene nanoribbons

N. Friedrich, P. Brandimarte, J. Li, S. Saito, S. Yamaguchi, I. Pozo, D. Peña, T. Frederiksen, A. Garcia-Lekue, D. Sánchez-Portal,* J. I. Pascual*

Phys. Rev. Lett. 2020, 125, 146801  DOI: 10.1103/PhysRevLett.125.146801





 98. Astrochemical relevance of vacuum UV ionization of large polycyclic aromatic hydrocarbon cations

G. Wenzel, C. Joblin,* A. Giuliani, S. Rodriguez Castillo, G. Mulas, M. Ji, H. Sabbah, S. Quiroga, D. Peña, L. Nahon

Astron. Astrophys. 2020, 641, A98  DOI: 10.1051/0004-6361/202038139






 97. Transferring axial molecular chirality through a sequence of on-surface reactions

N. Merino-Díez, M. S. G. Mohammed, J. Castro-Esteban, L. Colazzo, A. Berdonces-Layunta, J. Lawrence, J. Ignacio Pascual, D. G. de Oteyza,* D. Peña*

Chem. Sci. 2020, 11, 5441-5446      DOI: 10.1039/d0sc01653e










 96. Uncovering the Triplet Ground State of Triangular Graphene Nanoflakes Engineered with Atomic Precision on a Metal Surface

J. Li, S. Sanz, J. Castro-Esteban, M. Vilas-Varela, N. Friedrich, T. Frederiksen,* D. Peña,* J. I. Pascual*

Phys. Rev. Lett. 2020, 124, 177201    DOI: 10.1103/PhysRevLett.124.177201













95. Band depopulation of graphene nanoribbons induced by chemical gating with amino groups

J. Li, P. Brandimarte, M. Vilas-Varela, N. Merino-Díez, C. Moreno, A. Mugarza, J. Sáez Mollejo, D. Sánchez-Portal, D. G. de Oteyza, M. Corso, A. Garcia-Lekue,* D. Peña,* J. I. Pascual*

ACS Nano 202014, 1895-1901        DOI: 10.1021/acsnano.9b08162








94. Dodecacene generated on surface: reopening of the energy gap

F. Eisenhut, T. Kühne, F. García, S. Fernández, E. Guitián, D. Pérez, G. Trinquier, G. Cuniberti, C. Joachim, D. Peña,* F. Moresco*

ACS Nano 2020, 14, 1011-1017   DOI: 10.1021/acsnano.9b08456









93. Synthesis and reactivity of a trigonal porous nanographene on a gold surface

R. Zuzak, I. Pozo, M. Engelund, A. Garcia-Lekue, M. Vilas-Varela, J. M. Alonso, M. Szymonski, E. Guitián, D. Pérez, S. Godlewski,* D. Peña*

Chem. Sci. 2019, 10, 10143-10148         DOI: 10.1039/c9sc03404h










 92. Revisiting Kekulene: Synthesis and Single-Molecule Imaging

I. Pozo, Z. Majzik, N. Pavliček, M. Melle-Franco, E. Guitián, D. Peña,* L. Gross, D. Pérez*

J. Am. Chem. Soc. 2019, 141, 15488-15493    DOI: 10.1021/jacs.9b07926









 91. Molecular structure elucidation with charge-state control

S. Fatayer*, F. Albrecht, Y. Zhang, D. Urbonas, D. Peña, N. Moll, L. Gross*

Science 2019, 365, 142-145  DOI: 10.1126/science.aax5895






 90. Synthesis of Nanographenes, Starphenes, and Sterically Congested Polyarenes by Aryne Cyclotrimerization

I. Pozo, E. Guitián, D. Pérez, D. Peña*

Acc. Chem. Res. 2019, 52, 2472-2471  DOI: 10.1021/acs.accounts.9b00269








 89. Hierarchy in the Halogen Activation During Surface-Promoted Ullmann Coupling

N. Merino-Diez, A. Perez Paz, J. Li, M. Vilas-Varela, J. Lawrence, M. S. G. Mohammed, A. Berdonces-Layunta, A. Barragan, J. I. Pascual, J. Lobo-Checa, D. Peña, D. G. de Oteyza*

ChemPhysChem 2019, 20, 2305-2310         DOI: 10.1002/cphc.201900633






 88. Exploring a route to cyclic acenes by on-surface synthesis

F. Schulz, F. García, K. Kaiser, D. Pérez, E. Guitián, L. Gross*, D. Peña*

Angew. Chem. Int. Ed. 2019, 58, 9038-9042               DOI: 10.1002/anie.201902784                Open Access






 87. Electrically Addressing the Spin of a Magnetic Porphyrin through Covalently Connected Graphene Electrodes

J. Li,* N. Friedrich, N. Merino, D. G. de Oteyza, D. Peña, D. Jacob,* J. I. Pascual*

Nano Lett. 2019, 19, 3288-3294    DOI: 10.1021/acs.nanolett.9b00883








 86. Single spin localization and manipulation in graphene open-shell nanostructures

J. Li, S. Sanz, M. Corso, D. J. Choi, D. Peña, T. Frederiksen, J. I. Pascual*

Nature Comm. 2019, 10, 200                                 DOI: 10.1038/s41467-018-08060-6







 85. Critical Role of Phenyl Substitution and Catalytic Substrate in the Surface-Assisted Polymerization of Dibromobianthracene Derivatives

C. Moreno,* M. Panighel, M. Vilas-Varela, G. Sauthier, M. Tenorio, G. Ceballos, D. Peña,* A. Mugarza*

Chem. Mater. 2019, 31, 331-341    DOI: 10.1021/acs.chemmater.8b03094






 84. Bottom-up synthesis of multifunctional nanoporous graphene

C. Moreno,* M. Vilas-Varela, B. Kretz, A. Garcia-Lekue, M. V. Costache, M. Paradinas, M. Panighel, G. Ceballos, S. O. Valenzuela, D. Peña,* A. Mugarza*

Science 2018, 360, 199-203

DOI: 10.1126/science.aar2009

Dissemination movie: Nanoporous graphene for smart filters and sensors


 83. Controlled Fragmentation of Single Molecules with Atomic Force Microscopy by Employing Doubly Charged States

S. Fatayer,* N. Moll, S. Collazos, D. Pérez, E. Guitián, D. Peña, L. Gross,* G. Meyer

Phys. Rev. Lett. 2018, 121, 226101

DOI: 10.1103/PhysRevLett.121.226101

82. [19]Dendriphene: A 19-ring dendritic nanographene

M. Vilas-Varela, S. Fatayer, Z. Majzik, D. Pérez, E. Guitián, L. Gross, D. Peña*

Chem. Eur. J. 2018, 24, 17697

DOI: 10.1002/chem.201805140

 81. Atomic force microscopy identifying fuel pyrolysis products and directing the synthesis of analytical standards

S. Fatayer, N. Poddar, S. Quiroga, F. Schulz, B. Schuler, S. V. Kalpathy, G. Meyer, D. Pérez, E. Guitián, D. Peña*, M. J. Wornat*, L. Gross*

J. Am. Chem. Soc. 2018, 140, 8156

DOI: 10.1021/jacs.8b02525


 80. Studying an antiaromatic polycyclic hydrocarbon adsorbed on different surfaces

Z. Majzik*, N. Pavliček, M. Vilas-Varela, D. Pérez, N. Moll, E. Guitián, G. Meyer, D. Peña*, L. Gross

Nature Communications 2018, 9, 1198               DOI: 10.1038/s41467-018-03368-9

 79. Atomic Force Microscopy for Molecular Structure Elucidation

L. Gross*, B. Schuler, N. Pavlicek, S. Fatayer, Z. Majzik, N. Moll, D. Peña, G. Meyer

Angew. Chem. Int. Ed. 2018, 57, 3888              DOI: 10.1002/anie.201703509


 78. Survival of spin state in magnetic porphyrins contacted by graphene nanoribbons

J. Li*, N. Merino-Díez, E. Carbonell-Sanromà, M. Vilas-Varela, D. G. de Oteyza, D. Peña, M. Corso, J.I. Pascual*

Science Advances 2018, 4, eaaq0582                 DOI: 10.1126/sciadv.aaq0582


 77. Hexacene generated on passivated silicon

F. Eisenhut, J. Krüger, D. Skidin, S. Nikipar, J. M. Alonso, E. Guitián, D. Pérez, D. A. Ryndyk, D. Peña,* F. Moresco,* G. Cuniberti

Nanoscale 2018, 10, 12582                                DOI: 10.1039/c8nr03422b


 76. Building a 22-ring nanographene by combining in-solution and on-surface syntheses

R. Zuzak, J. Castro-Esteban, P. Brandimarte, M. Engelund, A. Cobas, P. Piatkowski, M. Kolmer, D. Pérez, E. Guitián, M. Szymonski, D. Sánchez-Portal, S. Godlewski,* D. Peña*

Chem. Commun. 2018, 54, 10256-10259            DOI: 10.1039/c8cc05353g


 75. On-surface synthesis of superlattice arrays of ultra-long graphene nanoribbons

C. Moreno,* M. Paradinas, M. Vilas-Varela, M. Panighel, G. Ceballos, D. Peña, A. Mugarza*

Chem. Commun. 2018, 54, 9402           Inside Cover        DOI: 10.1039/c8cc04830d


 74. Palladium-catalyzed cocyclotrimerization of arynes with a pyramidalized alkene

J. M. Alonso, S. Quiroga, S. Codony, A. L. Turcu, M. Barniol-Xicota, D. Pérez, E. Guitián, S. Vázquez, D. Peña*

Chem. Commun. 2018, 54, 5996                          DOI: 10.1039/c8cc03188f


 73. Microwave-induced covalent functionalization of few-layer graphene with arynes under solvent-free conditions

M. V. Sulleiro, S. Quiroga, D. Peña, D. Pérez, E. Guitián, A. Criado*, M. Prato*

Chem. Commun. 2018, 54, 2086           Cover       DOI: 10.1039/c7cc08676h


72. Electronic Resonances and Gap Stabilization of Higher Acenes on a Gold Surface

J. Krüger, F. Eisenhut, D. Skidin, T. Lehmann, D. A. Ryndyk, G. Cuniberti, F. García, J. M. Alonso, E. Guitián, D. Pérez, D. Peña, G. Trinquier, J.-P. Malrieu, F. Moresco*, C. Joachim

ACS Nano 2018, 12, 8506-8511                            DOI: 10.1021/acsnano.8b04046


 71. On-surface route for producing planar nanographenes with azulene moieties

J. Hieulle, E. Carbonell-Sanromà, M. Vilas-Varela, A. Garcia-Lekue, E. Guitián, D. Peña,* J. I. Pascual*

Nano Letters 2018, 18, 418-423                           DOI: 10.1021/acs.nanolett.7b04309


 70. Unraveling the Electronic Structure of Narrow Atomically Precise Chiral Graphene Nanoribbons

N. Merino-Díez, J. Li, A. Garcia-Lekue, G. Vasseur, M. Vilas-Varela, E. Carbonell-Sanromà, M. Corso, J. E. Ortega, D. Peña, J. I. Pascual, D. G. de Oteyza *

J. Phys. Chem. Lett 2018, 9, 25-30                       DOI: 10.1021/acs.jpclett.7b02767


 69. Site-selective reversible Diels–Alder reaction between a biphenylene-based polyarene and a semiconductor surface

S. Godlewski,* M. Engelund, D. Peña, R. Zuzak, H. Kawai,* M. Kolmer, J. Caeiro, E. Guitián, K. P. C. Vollhardt, D. Sánchez-Portal, M. Szymonski, D. Pérez*

Phys. Chem. Chem. Phys. 2018, 20, 11037           Hot article DOI: 10.1039/c8cp01094c


 68. Addressing Long-Standing Chemical Challenges by AFM with Functionalized Tips

D. Peña,* N. Pavliček, B. Schuler, N. Moll, D. Pérez, E. Guitián, G. Meyer, L. Gross

Advances in Atom and Single Molecule Machines

On-Surface Synthesis II                                         ISBN: 978-3-319-75809-1

Eds. D. G. de Oteyza and C. Rogero, Springer 2018, 209-227


 67. Homocoupling of terminal alkynes on calcite (10.4)

A. Richter, M. Vilas-Varela, D. Peña, R. Bechstein, A. Kühnle

Surface Science 2018, 678, 106-111                               DOI: 10.1016/j.susc.2017.12.012





66. Decacene: On-surface generation

J. Krüger, F. García, F. Eisenhut, D. Skidin, J. M. Alonso, E. Guitián, D. Pérez, G. Cuniberti, F. Moresco,* D. Peña*

Angew. Chem. Int. Ed. 2017, 56, 11945-11948.        Hot article  DOI: 10.1002/anie.201706156


65. Generation and Characterization of a meta-Aryne on Cu and NaCl Surfaces

N. Pavlicek, Z. Majzik, S. Collazos, G. Meyer, D. Perez, E. Guitián, D. Peña,* L. Gross*

ACS Nano 2017, 11, 10768−10773                            DOI: 10.1021/acsnano.7b06137



64. Doping of Graphene Nanoribbons via Functional Group Edge Modification

E. Carbonell-Sanromà,* J. Hieulle, M. Vilas-Varela, P. Brandimarte, M. Iraola, A. Barragán, J. Li, M. Abadia, M. Corso, D. Sánchez-Portal, D. Peña,* J. I. Pascual*

ACS Nano 2017, 11, 7355−7361                                DOI: 10.1021/acsnano.7b03522



63. Characterizing aliphatic moieties in hydrocarbons with atomic force microscopy

B. Schuler,* Y. Zhang,* S. Collazos, S. Fatayer, G. Meyer, D. Pérez, E. Guitián, M. R. Harper, J. D. Kushnerick, D. Peña*, L. Gross

Chem. Sci. 2017, 8, 2315-2320                                  DOI: 10.1039/C6SC04698C



62. Molecular Self-Assembly Driven by On-Surface Reduction: Anthracene and Tetracene on Au(111)

J. Krüger, F. Eisenhut, T. Lehmann, J. M. Alonso, J. Meyer, D. Skidin, R. Ohmann, D. A. Ryndyk, D. Perez, E. Guitián, D. Peña, F. Moresco,* G. Cuniberti

J. Phys. Chem. C 2017, 121, 20353−20358                 DOI: 10.1021/acs.jpcc.7b06131



61. Heavy Oil Based Mixtures of Different Origins and Treatments Studied by Atomic Force Microscopy

B. Schuler,* S. Fatayer, G. Meyer, E. Rogel, M. Moir, Y. Zhang, M. R. Harper, A. E. Pomerantz, K. D. Bake, M. Witt, D. Peña, J. D. Kushnerick, O. C. Mullins, C. Ovalles, F. G. A. van den Berg, L. Gross*

Energy & Fuels 2017, 31, 6856–6861                             DOI: 10.1021/acs.energyfuels.7b00805



60. Imaging the electronic structure of on-surface generated hexacene

J. Krüger, F. Eisenhut, J. M. Alonso, T. Lehmann, E. Guitián, D. Pérez, D. Skidin, F. Gamaleja, D. A. Ryndyk, C. Joachim, D. Peña,* F. Moresco,* G. Cuniberti

Chem. Commun. 2017, 53, 1583-1586                  Front cover            DOI: 10.1039/c6cc09327b



59. Straightforward Synthesis of a Vicinal Double-Bridgehead Iodo Trimethylsilyl Octacycle: Unprecedented Lack of Reactivity of the Silyl Group in the Presence of Fluoride Anions

P. Camps,* D. Lozano, E. Guitián, D. Peña, D. Perez, M. Font-Bardia, A. L. Llamas-Saiz

Eur. J. Org. Chem. 2017, 1594–1603                           DOI: 10.1002/ejoc.201601618



58. Reversible Bergman cyclization by atomic manipulation

B. Schuler, S. Fatayer, F. Mohn, N. Moll, N. Pavliček, G. Meyer, D. Peña, L. Gross*

Nature Chemistry 2016, 8, 220-224.                      Front Cover         DOI: 10.1038/NCHEM.2438

Dissemination movie  573.000 visualizations (29/10/2018)



57. Substrate-Independent Growth of Atomically Precise Chiral Graphene Nanoribbons

D. G. Oteyza*, A. G. Lekue, M. Villas-Varela, N. Merino-Diez, E. Carbonell, M. Corso, G. Vasseur, C. Rogero, E. Guitián, J. I. Pascual, E. Ortega, Y. Wakayama, D. Peña*

ACS Nano 2016, 10, 9000-9008.                                                           DOI: 10.1021/acsnano.6b05269



56. Tetracene Formation by On-Surface Reduction

J. Krüger, N. Pavliček, J. M. Alonso, D. Pérez, E. Guitián, T. Lehmann, G. Cuniberti, A. Gourdon, G. Meyer, G., L. Gross, F. Moresco*, D. Peña*

ACS Nano 2016, 10, 4538-4542                                                            DOI: 10.1021/acsnano.6b00505A



55. C60-aryne building block: synthesis of a hybrid all-carbon nanostructure

D. Garcia, L. Rodriguez-Perez, M. A. Herranz, D. Peña, E. Guitián, S. Bailey, Q. Al-Galiby, M. Noori, C. J. Lambert, D. Perez*, N. Martín*

Chem. Commun. 2016, 52, 6677                                                           DOI: 10.1039/c5cc10462a



54. 1,7-Naphthodiyne: a new platform for the synthesis of novel, sterically congested PAHs

I. Pozo, A. Cobas, D. Peña, E. Guitián, D. Pérez*

Chem. Commun., 2016, 52, 5534-5537                                                 DOI: 10.1039/c6cc01214k



53. Tunable Band Alignment with Unperturbed Carrier Mobility of On-Surface Synthesized Organic Semiconducting Wires

A. Basagni, G. Vasseur, C. A. Pignedoli, M. Vilas-Varela, D. Peña, L. Nicolas, L. Vitali, J. Lobo-Checa, D. G. de Oteyza, F. Sedona,* M. Casarin, J. E. Ortega, M. Sambi

ACS Nano 2016, 10, 2644-2651                                                            DOI: 10.1021/acsnano.5b07683




52. On-surface generation and imaging of arynes by atomic force microscopy

N. Pavlicek*, B. Schuler, S. Collazos, N. Moll, D. Pérez, E. Guitián, G. Meyer, D. Peña*, L. Gross

Nature Chemistry 2015, 7, 623-628. Front Cover         

DOI: 10.1038/nchem.2300

Dissemination movie: IBM Research and CIQUS scientists first to image short-lived molecules



51. Unraveling the molecular structures of asphaltenes by atomic force microscopy

B. Schuler*, G. Meyer, D. Peña, O. C. Mullins, L. Gross*

J. Am. Chem. Soc. 2015, 137, 9870-9876                                             DOI: 10.1021/jacs.5b04056

Highlighted in Chemistry World (11/08/2015)



50. Large phenyl-substituted acenes by cycloaddition reactions of the 2,6-naphthopdiyne synthon

D. Rodríguez-Lojo, D. Pérez*, D. Peña*, E. Guitián

Chem. Commun. 2015, 51, 5418-5420                                                  DOI: 10.1039/c5cc00205b



49. Aryl Halide C−C Coupling on Ge(001):H Surfaces

P. Olszowski, B. Zapotoczny, J. S. Prauzner-Bechcicki,* M. Vilas-Varela, D. Pérez, E. Guitián, D. Peña, M. Szymonsk

J. Phys. Chem. C 2015, 119, 27478−27482                                          DOI: 10.1021/acs.jpcc.5b08883



48. Straightforward synthesis of novel acene-based aryne precursors

D. Rodríguez-Lojo, D. Peña, D. Pérez, E. Guitián

Synlett 2015, 26, 1633-1637




47. From Perylene to a 22-Ring Aromatic Hydrocarbon in One-Pot

B. Schuler, S. Collazos, L. Gross, G. Meyer, D. Pérez, E. Guitián, D. Peña*

Angew. Chem. Int. Ed. 2014, 53, 9004-9006.                                        DOI: 10.1002/anie.201403707



46. Acid-promoted aromatization of perylene-based endoxides

A. Criado, M. Vilas-Varela, A. Cobas, D. Pérez, D. Peña, E. Guitián

Heterocyles 2014, 88, 1625-1632




45. Stereoselective tandem cascade furan cycloadditions

A. Criado, M. Vilas-Varela, A. Cobas, D. Pérez, D. Peña*, E. Guitián*

J. Org. Chem. 2013, 78, 12637-12649                                                   DOI: 10.1021/jo4022265



44. Efficient cycloaddition of arynes to carbon nanotubes under microwave irradiation

A. Criado, M. Vizuete, M. J. Gomez-Escalonilla, S. Garcia-Rodriguez, J. L. G. Fierro, A. Cobas, D. Peña, E. Guitián, F. Langa*

Carbon 2013, 63, 140-148                                                                     DOI: 10.1016/j.carbon.2013.06.064



43. One-pot synthesis of sterically congested large aromatic hydrocarbons via 1,4-diphenyl-2,3-triphenylyne

D. Rodríguez-Lojo, D. Pérez*, D. Peña*, E. Guitián

Chem. Commun 2013, 49, 6274-6276                                                   DOI: 10.1039/c3cc43103g



42. Aryne Cycloaddition Reactions in the Synthesis of Large Polycyclic Aromatic Compounds

D. Pérez*, D. Peña*, E. Guitián

Eur. J. Org. Chem. 2013, 5981-6013                                                     DOI: 10.1002/ejoc.201300470




41. Bond Order Discrimination by Atomic Force Microscopy

L. Gross*, F. Mohn, N. Moll, B. Schuler, A. Criado, E. Guitián, D. Peña, A. Gourdon, G. Meyer

Science 2012, 337, 1326-1329.                             Front cover            DOI: 10.1126/science.1225621



40. [16]Cloverphene: a clover-shaped cata-condensed nanographene with sixteen fused benzene rings

J. M. Alonso, A. Díaz-Álvarez, D. Pérez, D. Peña,* E. Guitián

Angew. Chem. Int. Ed. 2012, 51, 173-177



39. Aryne Insertion into I–I σ-Bonds

D. Rodríguez-Lojo, A. Cobas, D. Peña, D. Pérez,* E. Guitián*

Org. Lett. 2012, 14, 1363-1365




38. Highly selective insertion of arynes into a C(sp)-O(sp3) sigma bond

K. Z. Laczkowski, D. García, D. Peña,* A. Cobas, D. Pérez, E. Guitián*

Org. Lett. 2011, 13, 960-963



37. Cycloaddition of Benzyne to SWCNT: Towards CNT-Based Paddle Wheels

A. Criado, M. J. Gómez-Escalonilla, J. L. G. Fierro, A. Urbina, D. Peña, E. Guitián,* F. Langa*

Chem. Commun. 2010, 7028-7030



36. Domino Diels-Alder Cycloadditions of Arynes: New Approach to Elusive Perylene Derivatives

A. Criado, D. Peña,* A. Cobas, E. Guitián*

Chem. Eur. J. 2010, 16, 9736-9740                                       Inside Cover



35. Aryne-mediated syntheses of structurally related acene derivatives

D. Rodríguez-Lojo, D. Peña,* D. Pérez,* E. Guitián

Org. Biomol. Chem. 2010, 8, 3386-3388



34. Bottom-Up Approaches to Nanographenes through Organic Synthesis

Diego Peña*

Ideas in Chemistry and Molecular Sciences: Advances in Synthetic Chemistry  

Ed. B. Pignataro, Wiley-VCH, 2010, Chapter 11



33. Generation and Reactivity of 1,2-Cyclohexadiene Under Mild Reaction Conditions

I. Quintana, D. Peña,* D. Pérez, E. Guitián*

Eur. J. Org. Chem. 2009, 5519-5524                                     Front Cover



32. Structural characterization and physical properties of new tetrabenzopentaphene mesogens

C. Romero, D. Peña, D. Pérez, E. Guitián,* R. Termine, A. Golemme, A. Omenat, J. Barberá, J. L. Serrano*

J. Mater. Chem. 2009, 19, 4725-4731



31. Palladium-Catalyzed [2 + 2 + 2] Cycloadditions of 3,4-Didehydrophenanthrene and 1,2-Didehydrotriphenylene

C. Romero, D. Peña, D. Pérez, E. Guitián

J. Org. Chem. 2008, 73, 7996-8000



30. Aryne-Mediated Synthesis of Heterocycles

D. Peña, D. Pérez, E. Guitián

Heterocycles 2007, 74, 89-100



29. Cyclotrimerization Reactions of Arynes and Strained Cycloalkynes

D. Peña, D. Pérez, E. Guitián

Chem. Rec. 2007, 7, 326-333



28. Reaction of Benzyne with Styrene Oxide: Insertion of Arynes into a C-O bond of Epoxides

S. Beltrán-Rodil, D. Peña, E. Guitián

Synlett 2007, 1308-1310



27. Catalysis in the [2+2+2] Cycloaddition of Arynes and Alkynes: Enantioselective Synthesis of a Pentahelicene

J. Caeiro, D. Peña, A. Cobas, D. Pérez, E. Guitián

Adv. Synth. Catal. 2006, 348, 2466- 2474



26. Synthesis and Reactivity of New Strained Cyclic Allene and Alkyne Precursors

D. Peña, B. Iglesias, I. Quintana, D. Pérez, E. Guitián, L. Castedo

Pure Appl. Chem. 2006. 78, 451-455



25. Insertion of Arynes into sigma-Bonds

D. Peña, D. Pérez, E. Guitián

Angew. Chem. Int. Ed.  2006, 45, 3579-3581



24. Metal-Catalyzed Cotrimerization of Arynes and Alkenes

I. Quintana, A. J. Boersma, D. Peña, D. Pérez, E. Guitián

Org. Lett. 2006, 8, 3347-3349



23. On the Mechanism of the Copper-Catalyzed Enantioselective 1,4-Addition of Grignard Reagents to a,b-Unsaturated Carbonyl Compounds

S. R. Harutyunyan, F. López, W. R. Browne, A. Correa, D. Peña, R. Badorrey, A. Meetsma, A. J. Minnaard, B. L. Feringa

J. Am. Chem. Soc. 2006, 128, 9103-9118



22. Synthesis of Extended Triphenylenes by Palladium-Catalyzed [2+2+2] Cycloaddition of Triphenylynes

C. Romero, D. Peña, D. Pérez, E. Guitián

Chem. Eur. J. 2006, 12, 5677-5684



21. Palladium-catalyzed cycloaddition reactions of arynes

E. Guitián, D. Pérez, D. Peña


Springer Verlag; 2005, Vol: 14, 109-146



20. Improved Catalytic Asymmetric Carbon-Carbon Bond Formation Using Combinations of Chiral and Achiral Monodentate Ligands

A. Duursma, D. Peña, A. J. Minnaard, B. L. Feringa

Tetrahedron-Asymmetry 2005, 16, 1901-1904



19. Tandem one pot asymmetric conjugate addition-vinyl triflate formation-cross coupling methodology

R. M. Suárez, D. Peña, A. J. Minnaard, B. L. Feringa

Org. Biomol. Chem. 2005, 3, 729-731 



18. Copper-catalyzed asymmetric conjugate addition of grignard reagents to cyclic enones

B. L. Feringa, R. Badorrey, D. Peña, S. R. Harutyunyan, A. J. Minnaard

Proc. Natl. Acad. Sci. (PNAS) 2004, 101, 5834-5838



17. Highly enantioselective Cu-catalysed asymmetric 1,4-addition of diphenylzinc to cyclohexanone

D. Peña, F. López, S. R. Harutyunyan, A.J. Minnaard, B. L. Feringa

Chem. Commun. 2004, 1836-1837



16. Diastereoselective remote C-H activation by hydroboration

J. A. Varela, D. Peña, B. Goldfuss, D. Denisenko, J. Kulhanek, K. Polborn, P. Knochel

Chem. Eur. J. 2004, 10, 4252-4264



15. Dibenzo[a,o]phenanthro[3,4-s]pycene, a Configurationally Stable Double Helicene: Synthesis, and Determination of Its Conformation by NMR and GIAO Calculations

D. Peña, A. Cobas, D. Pérez, E. Guitián, L. Castedo

Org. Lett. 2003, 5, 1863-1866 



14. Improving conversion and enantioselectivity in hydrogenation by combining different monodentate phosphoramidites: a new combinatorial approach in asymmetric catalysis

D. Peña, A. J. Minnaard, J. A. F. Boogers, A. H. M. de Vries, J. G. de Vries, B. L. Feringa

Org. Biomol. Chem. 2003, 1, 1087-1089



13. Mono- versus bidentate ligands in rhodium-catalyzed asymmetric hydrogenation. A comparative rate study

D. Peña, A. J. Minnaard, A. H. M. de Vries, J. G. de Vries, B. L. Feringa

Org. Lett. 2003, 5, 475-478



12. First Partially Intramolecular Palladium-catalyzed [2+2+2]-Cycloaddition of Benzyne: Application to the Synthesis of Benzo[b]fluorenones

D. Peña, D. Pérez, E. Guitián, L. Castedo

Eur. J. Org. Chem. 2003, 1238-1243



11. An Efficient Procedure for the Synthesis of ortho-Trialkylsilylaryl Triflates: Easy Access to Precursors of Functionalized Arynes

D. Peña, A. Cobas, D. Pérez, E. Guitián

Synthesis 2002, 1454-1458



10. Highly enantioselective rhodium-catalyzed hydrogenation of beta-dehydroamino acid derivatives using monodentate phosphoramidites

D. Peña, A. J. Minnaard, J. G. de Vries, B. L. Feringa

J. Am. Chem. Soc. 2002, 124, 14552-14553



9. Palladium-Catalyzed Trimerization of Strained Cycloalkynes. Synthesis of Decacyclene

B. Iglesias, D. Peña, D. Pérez, E. Guitián, L. Castedo

Synlett 2002, 486-488



8. Mechanism and application of the remote C-H activation of phenyl substituted alkenes by BH3.THF

J. Varela, D. Peña, B. Goldfuss, K. Polborn, P. Knochel

Org. Lett. 2001, 3, 2395-2398



7. 2-(Trimethylsilyl)phenyl Trifluoromethanesulfonate

Diego Peña

Synlett 2001, 1662-1662



6. Synthesis of Polycyclic Aromatic Hydrocarbons by Cocyclization of Arynes and Dimethyl Acetylenedicarboxylate (DMAD)

D. Peña, D. Pérez, E. Guitián, L. Castedo

Synlett 2000, 1061-1063



5. Selective Palladium-catalyzed Cocyclotrimerization of Arynes with DMAD: A Versatile Method for the Synthesis of Polycyclic Aromatic Hydrocarbons (PAHs)

D. Peña, D. Pérez, E. Guitián, L. Castedo

J. Org. Chem. 2000, 65, 6944-6950



4. Kinetic Control in the Palladium-catalyzed Synthesis of C2-symmetric Hexabenzotriphenylene. A Conformational Study

D. Peña, A. Cobas, D. Pérez, E. Guitián, L. Castedo

Org. Lett. 2000, 2, 1629-1632



3. Synthesis of hexabenzotriphenylene and other strained polycyclic aromatic hydrocarbons by palladium-catalyzed cyclotrimerization of arynes

D. Peña, D. Pérez, E. Guitián, L. Castedo

Org. Lett. 1999, 1, 1555-1557


2. Palladium-catallyzed cocyclization of arynes with alkynes: selective synthesis of phenanthrenes and naphtalenes

D. Peña, D. Pérez, E. Guitián, L. Castedo

J. Am. Chem. Soc. 1999, 121, 5827-5828



1. Efficient palladium-catalyzed cyclotrimerization of arynes: Synthesis of triphenylenes

Diego Peña, Sonia Escudero, Dolores Pérez, Enrique Guitián, Luis Castedo

Angew. Chem. Int. Ed. 1998, 37, 2659-2661