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Páxinas persoais  »  Antonio Mouriño Mosquera

List of Publications and Patents

THE MOURIÑO GROUP

  

 

 PUBLICATIONS

 

(165) Otero R, Seoane S, Sigüeiro R, Belorusova A, Maestro M. A, Pérez-Fernández R, Rochel N, Mouriño A.
Carborane-Based Design of a Potent Vitamin D Receptor Agonist.
Chem. Sci. 2016, 7, 1033-1037 (IF = 9.21)
 
(164) Sigüeiro R, Otero R, González-Berdullas,P, Maestro M, Mouriño A.
An Efficient Convergent Synthesis of 1a,25-dihydroxy-3-epi-vitamin D2.
J. Steroid Biochem. Mol. Biol. 2015, 148, 31-33. (IF = 3.63)
 
(163) Kulesza U, Plum LA, DeLuca HF,Mouriño A, Sicinski
A new suprasterol by photochemical reaction of 1a,25-dihydroxy-9-methylene-19-norvitamin D.
Org. Biomol. Chem. 2016, 14, 1646-1652. (IF = 3.56)
 
(162) Watarai Y, Ishizawa M, Ikura T, Zacconi F, Uno S, Ito N, Mouriño A, Tokiwa H, Makishima M, Yamada S.
Synthesis, Biological Activities and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds
J. Med. Chem. 2015, 58, 9510−9521 (IF = 5.45)
 
(161) Loureiro J, Maestro M. A. Mouriño A, Sigüeiro R.
Stereoselective Synthesis of 1b,25-Dihydroxyvitamin D3 and its 26,27-Hexadeuterated Derivative.
J. Steroid Biochem. Mol. Biol. 2015, DOI: 10.1016/j.jsbmb.2015.09.007. (IF = 3.63)
 
(160) Kulesza U, Plum L, Deluca H; Mouriño A, Sicinski R.
Novel 9-Alkyl- and 9-Alkylidene-substituted 1α,25-Dihydroxyvitamin D Analogues: Synthesis and Biological Examinations"
J. Med. Chem. 2015, 58, 6237-6247. (IF = 5.45)
 
(159) Seoane S, Arias E, Sigüeiro R, Sendon-Lago J, Martínez-Ordoñez A, Castelao E, Eiró N, García-Caballero T, Macía M, López-López R, Maestro M, Vizoso F, Mouriño A, Pérez-Fernández R.
Pit-1 inhibits BRCA1 and sensitize human breast tumors to cisplatin and vitamin D tretament R.
Oncotarget 2015, 6, 14456-71. (IF = 6.36).
 
(158) Sokolowska K, Carballa D , Seoane S, Pérez-Fernández R, Mouriño A, Sicinski R
Synthesis and Biological Activity of Two C-7 Methyl Analogues of Vitamin D.
J. Org. Chem. 2015, 80, 165–173. (IF = 4.72).
 
(157) Mena-Bravo A, Ferreiro-Vera C, Priego-Capote F, Maestro M. A,., Mouriño, A, Quesada-Gómez J. M, Luque de Castro M.D.
Quantitative analytical method to evaluate the metabolism of vitamin D.
Clin. Chim. Acta 2015, 442, 6-13. (IP = 2.82)
 
(156) Sigüeiro R, Álvarez A, Otero R, López-Pérez B, Regueira P, González-Berdullas P, Seoane S, Pérez-Fernández, Mouriño A, Maestro MA.
Synthesis of Nonadeuterated 1a,25-Dihydroxyvitamin D3.
J. Steroid Biochem. Mol. Biol. 2014, 144, 204-206. (IF = 3.63)
 
(155) Kaufmann M, Gallagher JC, Peacock M, Schlingmann K-P, Konrad M, DeLuca HF, Sigueiro R, Lopez B, Mourino A, Maestro M, St-Arnaud R, Finkelstein JS, Cooper DP, Jones G.
Clinical Utility of Simultaneous Quantitation of 25-Hydroxyvitamin D and 24,25-Dihydroxyvitamin D by LC-MS/MS Involving Derivatization With DMEQ-TAD.
J. Clin. Endocrinol. Metab. 2014, 99, 2569-2574. (IF= 5.925).
 
(154) Seoane S, Bermúdez MA, Sendon-Lago J, Martínez-Ordoñez  A, Abdul-Hadi S, Maestro M, Mouriño A, Pérez-Fernández R.
26,26,26,27,27,27-Hexadeuterated-1,25-Dihydroxyvitamin D3 (1,25D-d6) As Adjuvant of Chemotherapy in Breast Cancer Cell Lines.
Cancers 2014, 6, 67-78. (IF = NUEVO)
 
(153) Rhieu SY, Analora AJ, Wang G, Flarakos CC, Gathungu RM, Vouros P, Sigüeiro R, Mouriño A, Schuster I, GTR Palmore, Reddy GS.
Metabolic Stability of 3-Epi-1α,25-Dihydroxyvitamin D3 Over Its Patent, 1α,25-DihydroxyvitaminD3: Comparative Metabolmism and Molecular Docking Studies Using Rat CYP24A1.
J. Cell Biochem. 2013, 114, 2293-2305. (IF = 3.37).
 
(152) Sokolowska K, Sicinski R, Mouriño A, Plum LA, DeLuca HF
Synthesis and biological evaluation of novel 6-substitued analogs of 1a,25-dihydroxy-19-norvitamin D3
J. Steroid Biochem. Mol. Biol. 2013, 136, 30-33. (IF = 4.05).
 
(151) Fraga R, López-Pérez B, Sokolowska K, Guini G, Regueira T, Díaz S, Mouriño A, Maestro MA
An efficient synthesis of 1a,25-dihydroxy-20-epi-vitamin D3
J. Steroid Biochem. Mol. Biol. 2013, 136, 14-1. (IF = 4.05).
 
(150) Kulesza U, Mouriño A, Plum LA, DeLuca HF, Sicinski RR.
Synthesis of novel 19-norvitamin D3 analogs with unnatural triene system.
J Steroid Biochem. Mo.l Biol. 2013, 136, 23-26. (IF = 4.05).
 
(149) Kulesza U, Mouriño A, Plum LA, DeLuca HF, Sicinski RR.
Synthesis of novel 19-norvitamin D3 analogs with unnatural triene system.
J Steroid Biochem. Mo.l Biol. 2013, 136, 23-26.
 
(148) Kulesza U, Sigüeiro R, Mouriño A, Sicinski RR.
Synthesis of 9-Alkylated Calcitriol and Two 1a,25-Dihydroxy-9-methylene-10,19-dihydroxvitamin D3. Analogs with Non-natural Triene by Thermal Sigmatropic Rearrangents
J. Org. Chem. 2013, 78, 1444-1450.
 
(147) Carballa DM, Rumbo A, Torneiro M, Maestro M, Mouriño A
Synthesis of 1α,25-Dihydroxyvitamin D3 with a b-Positioned Seven-Carbon Side Chain at C(12)
Helv. Chim. Acta (In honor of Prof. D. Seebach) .2012, 95, 1842-1850.
 
(146) Carballa DM, Zacconi F, Kulesza U, Mouriño A , Torneiro M
Synthesis of 1α,25-Dihydroxyvitamin D3 Analogues with a-Hydroxyalkyl Substituents at C12.
J. Steroid Biochem. Mol. Biol. 2013, 136, 34-38.
 
(145) Carballa DM, Seoane S, Zacconi F, Pérez X, Rumbo A, Alvarez-Díaz S, Larriba MJ, Pérez-Fernández R, Muñoz A, Maestro M, Mouriño A, Torneiro M.
Synthesis and Biological Evaluation of 1α,25-Dihydroxyvitamin D3 Analogues with a Long Side Chain at C12 and Short C17 Side Chains.
J. Med. Chem. 2012, 55, 8642–8656.
 
(144) Carlberg C, Molnár F, Mouriño A.
Vitamin D Receptor Ligands: The Impact of Crystal Structures
Expert Opin. Ther. Patents 2012, 22, 417-435.
 
(143) Fraga R, Zacconi F, Sussman F, Ordóñez-Morán P, Alberto Muñoz A, Huet T, Molnár F, Moras D, Rochel N, Maestro M, Mouriño A.
Design, Synthesis, Evaluation and Structure of Vitamin D Analogues with Furan Side Chains.
Chem. Eur. J. 2012, 18, 603-612.
 
(142) Regueira M, Samanta S, Malloy PJ, Ordoñez-Moran P, Resende D, Sussman F, Muñoz A, Mouriño A, Feldman D, Torneiro M.
Synhesis and Biological Evaluation of 1a,25-Dihydroxyvitamin D3 Analogues Hydroxymethylated at C-26.
J. Med. Chem. 2011, 44, 4677-4687.
 
(141) Molnar F, Sigüeiro R, Sato Y, Araujo C, Schuster I, Anthony P, Peluso J, Muller C, Mouriño A, Moras D, Rochel N.
Crystal Structure of the Vitamin D Receptor Complexed to its Natural Metabolite 1,25-Dihydroxy-3-epi-vitamin D3.
PLoS ONE. 2011, 66, e18124.
 
(140) Verlinden L,Verstuyf A,Guy Eelen,Bouillon R,Ordóñez-Morán P,Larriba MJ,Muñoz A,Rochel N,Sato Y, Moras D,Maestro M,Seoane S,Domínguez F,Eduardo-Canosa S,Nicoletti D, Moman E, Mouriño A.
Synthesis, Structure, and Biological Activity of des-Side Chain Analogues of 1,25-Dihydroxyvitamin D3 with Substituents at C-18.
ChemMedChem. 2011, 6, 788-793.
 
(139) Rumbo A, Pérez-García X, Mouriño A.
Stereselective Synthesis of C24-Hydroxylated Vitamin D3 Analogs. A Practical and Expeditius Route to Calcipotriol
J. Steroid Biochem. Molec. Biol. 2010, 121, 68-70.
 
(138) Nicoletti D,Gregorio C, Maestro M, Mouriño A.
A Short Practical Approach to 24R,25-Dihydroxyvitamin D3
J. Steroid Biochem. Molec. Biol. 2010, 121, 43-45.
 
(137) Sokolowska K, Mouriño A, Sicinski RR, Plum LA, DeLuca HF.
Synthesis and Biological Evaluation oF 6-AlkylatedAnalogs of 1α,25-Dihydroxyvitamin D3.
J. Steroid Biochem. Molec. Biol. 2010, 121, 29-33.
 
(136) Eduardo-Canosa S, Fraga R, Sigüeiro R, Marco M, Rochel N, Moras D, Mouriño A.
Design and Synthesis of Active Vitamin D Analogs
J. Steroid Biochem. Molec. Biol. 2010, 121, 7-12.
 
(135) Anthony P, Sigüeiro R, Huet T, Sato Y, Ramalanjaona N, Rodrigues LC, Mouriño A, Moras D, RochelN.
Structure-function Relationships and Crystal Structures of the Vitamin D Receptor Bound 2-methyl-20S,23S- and 23R Epoxymethano-1,25-Dihydroxyvitamin D3  
J. Med. Chem. 2010, 53, 1159-1171.
 
(134) Pranjal G, Sigüeiro R, Eduardo S, Mouriño A.
An Expeditious Route to 1,25-Dihydroxyvitamin D3 Analogs via Aquous Tandem Palladium Catalyzed A-Ring Closure and Suzuki Coupling with C/D Unit
Chem. Eur. J. 2010, 16, 1432-1435.
 
(133) Nicoletti D, Mouriño A, Torneiro M.
Synthesis of 25-Hydroxyvitamin D3 and 26,26,26,27,27,27-Hexadeutero-25-hydroxyvitamin D3 on Solid Support
J. Org. Chem. 2009, 73, 4782-4786.
 
(132) Rodríguez M, Rivas J, López-Quintela A, Mouriño A, Torneiro M.
In fluence of the S-Au Bond Strength on the Magnetic Behavior of S-Capped Au Nanoparticles
Nanomaterials for Applications in Medicine and Biology. Springer Science + Business Media B.V. 2008, 113-125
 
(131) HouraiS, Rodrigues LC, Antony P, Reina-San-Martin B, CiesielskiF, MagnierB, Schoonjans K, MouriñoA, Rochel  N, MorasD.
Structure-based design of a superagonist ligand for the nuclear receptor of vitamin D
Chem. Biol. 2008, 15, 383-392.
 
(130) Rochel N, Hourai S, Perez-Garcia X, Rumbo A, Mouriño A, Moras D.
Crystal Structure of the Vitamin D Nuclear Receptor Ligand Binding Domain in Complex with a Locked Side Chain Analog of Calcitriol.
Arch. Biochem. Biophys. 2007, 460(2), 172-176.
 
(129) Riveiros R, Rumbo A, Sarandeses LA, Mouriño A.
Synthesis and Conformational Analysis of New 17,21-Cyclo-22-Unsaturated Analogues of Calcitriol.
J. Org. Chem. 2007, 72, 5777-5485 (PORTADA).
 
(128) Maestro M,Gómez-Reino C, Nicoletti D, Sigüeiro R, Mallo R, Guini A, Mouriño A.
Novel Synthetic Approach to 1a,25-Didroxyvitamin D3 and Analogues.
J. Steroid Biochem. Molec. Biol. 2007, 103, 231-234.
 
(127) Gregorio C, Eduardo S, Rodrigues LC, Regueira MA, Fraga R, Maestro M, Mouriño A.
Synthesis of two Carboxylic Haptens for Raising Antibodies to 25-Hydroxyvitamin D3 and 1a,25-Dihydroxyvitamin D3.
J. Steroid Biochem. Molec. Biol. 2007,103, 227-230.
 
(126) Rodríguez E, Rivas J, Blanco CB, Mouriño A, Torneiro M, López-Quintela MA
Functionalization of Atomic Cobalt Clusters Obtained by Electrochemical Methods
Physica Statu Solidi A  2006, 1223-1228.
 
(125) Moman E, Nicoletti D, Mouriño A.
Strained polycycles by H5C5x Free-Radical Cascades
Org. Lett. 2006, 8, 1249-1251.
 
(124) González-Avión XC, Mouriño A, Rochel N, Moras D.
Novel 1,25-Dihydroxyvitamin D3 Analogues with the Side Chain at C12.
J. Med. Chem. 2006, 49, 1509-1516.
 
(123) Gómez-Reino C, Vitale C, Maestro M, Mouriño, A.
Pd-Catalyzed Carbocyclization–Negishi Cross-Coupling Cascade: A Novel Approach to 1,25-Dihydroxyvitamin D and Analogues.
Org. Lett.2005, 7, 5885–5887.
 
(122) Cornella I, Suárez RM, Mouriño A, Pérez-Sestelo J, Sarandeses LA
Stereoselective Convergent Synthesis of 24-Substituted Metabolites and Analogues of Vitamin D3.
J. Steroid Biochem. Molec. Biol. 2004, 89-90, 19-23.
 
(121) Sussman F, Rumbo A, Villaverde MC, Mouriño A
Predicting the Cell Differentiation Activity of 1,25-Dihydroxyvitamin D3 Side Chain Analogues from Docking Simulations.
J. Med. Chem. 2004, 47, 1613-1616.
 
(120) Moman E, Nicoletti D, Mouriño A.
Synthesis of Novel Analogues of 1,25-Dihydroxyvitamin D3 with Side Chains at C-18.
J. Org. Chem. 2004, 69, 4615-4625.
 
(119) Pérez-García X,Antonio Rumbo, Larriba MJ, Ordóñez P, Muñoz, Mouriño A.
The First Locked Side Chain Analogs of Calcitriol (1,25-Dihydroxyvitamin D3) Induce Vitamin D Receptor Transcriptional Activity
Org. Lett. 2003, 5, 4033-4036.
 
(118) Carlberg C, Mouriño A.
New Vitamin D Receptor Ligands.
Expert Opin. Ther.Patents 2003, 13, 761-772.
 
(117) González-Avion X-C, Mouriño A.
The First C-12-Modified 1,25-Dihydroxyvitamin D3 Analogues Strongly Modulate the Affinity for the Vitamin D Receptor (VDR).
Org. Lett. 2003, 5, 2291-2293.
 
(116) Fernández-Gacio A, Mouriño A.
Studies on the Introduction of Photoreactive Group into the Vitamin D Skeleton.
Eur. J. Org. Chem. 2002, 15, 529-2534.
 
(115) Varela C, Nilsson K, Torneiro M, Mouriño A.
Synthesis of Tetracyclic Analogues of Calcitriol (1,25-Dihydroxyvitamin D3) with Side-Chain-Locked Spatial Orientation at C(20).
Helv. Chim. Acta  2002, 85, 3251-3261.
 
(114) Cornella I, Pérez-Sestel J, Mouriño A, Sarandeses L A.
Synthesis of New 18-Substituted Analogues of Calcitriol Using a Photochemical Remote Functionalization.
J. Org. Chem.2002, 67, 4707-4714
 
(113) Pérez-Sestelo J, Cornella I, de Uña O, Mouriño A, Sarandeses LA.
Título: Stereoselective Convergent Synthesis of 24,25-Dihydroxyvitamin D3 Metabolites: A Practical Approach.
Chem. Eur. J. 2002, 8, 2747-2752.
 
(112) Pérez-Sestelo J, de Uña O, Mouriño A, Sarandeses LA.
Synthesis of the First 24-Aminovitamin D3 Derivatives by Diastereoselective Conjugate Addition to a Chiral Methyleneoxazolidinone in Aqueous Media.
Synlett.  2002, 719-722.
 
(111) Fall Y, Barreiro C, Fernández C, Mouriño A.
Vitamin D Heterocyclic Analogues. 1. A Steroselective Route to CD Systems with Pyrazole Rings in their Side Chains.
Tetrahedron Lett. 2002, 43, 1433-1436.
 
(110) Fall Y, González V, Vidal B, Mouriño A
Stereoselective Synthesis of 22-oxacalcitriol (OCT) and analogues modified at C25.
Tetrahedron Lett. 2002, 43, 427-42.
 
(109) van Egmond HP, Mouriño A, Burdaspal PA, Boenke A, Arévalo F, Botana-Lopez LM, Bustos J, Dietrich R, Donald M, Soler JMF, Martinez AG, Hald B, Helle N, Hummert C, Ledoux M, Legarda T, Luckas B, Mesego A, Paulsch WE, Rodríguez-Vieytes M, Salgado C, Stockemer J, Usleber E, van den Top HJ, Walter L, Walter M, Winkler F.
"Development of Reference Materials for Paralytic Shellfish Poisoning Toxins."
Journal of AOAC International 2001, 84, 1668-1676. 
 
(108) Van den Top HJ, Boenke A, Burdaspal PA, Bustos J, Van Egmond HP, Legarda T, Mesego A, Mouriño A, Paulsch WE, Salgado C.
"The Development of Reference Materials for Paralytic Shellfish Poisoning Toxins in Lyophilized Mussel. II. Certification Study"
Food Addit. Contam. 2001,18(9), 810-824.
 
(107) Fall Y, Fernández C, González V, Mouriño A.
"Stereoselective Synthesis of (22R)-and (22S)-22-Methyl-1,25-Dihydroxyvitamin D3"
Synlett. 2001, 1567-1568.
 
(106) Fall Y, Fernández C, González V, Mouriño A.
"A Key Intermediate for the Convenient Synthesis of Series of Vitamin D3 Analogues with Modified Side
Chains"
Tetrahedron Lett. 2001, 42, 7815-7817.
 
 (105) Sestelo JP, Mouriño A, Sarandeses LA.
"The Design and Synthesis of Calcitriol 1,25-Dihydroxyvitamin D3 Dimers as Potential Chemical Inducers of Vitamin D Receptor Dimerization"
Vitamin D: Endocrine System. Structural, Biological, Genetic and Clinical Aspects"
Ed.: A.W. Norman, R. Bouillon, M. Thomasset.
University of California Press. Riverside 2000, 107-110.
 
(104) Maestro M, Fernández Gacio A, Vitale C, Riveiros R, Mouriño A.
"Synthesis of Vitamin D3 Analogues with Semi-Rigid Side Chains"
Vitamin D: Endocrine System. Structural, Biological, Genetic and Clinical Aspects"
Ed.: A.W. Norman, R. Bouillon, M. Thomasset.
University of California Press. Riverside2000, 103-105.
 
(103) Fall Y, Fernández C, González V, Vitale C, Mouriño A.
"Stereoselective Synthesis of Vitamin D3 Analogues with Cyclic Side Chains"
Vitamin D: Endocrine System. Structural, Biological, Genetic and Clinical Aspects"
Ed.: A.W. Norman, R. Bouillon, M. Thomasset.
University of California Press. Riverside2000, 99-101.
 
(102) Torneiro M, Fall Y, Vitale C, Avión J, Mouriño A.
"An Espeditious Route to 25-Hydroxy Windaus-Grundmann Ketone"
Vitamin D: Endocrine System. Structural, Biological, Genetic and Clinical Aspects"
Ed.: A.W. Norman, R. Bouillon, M. Thomasset.
University of California Press. Riverside2000, 97-98.
 
(101) Pérez-Sestelo J, Mouriño A, Sarandeses LA.
“Synthesis of Vitamin D3 and Calcitriol Dimers as Potential Chemical Inducers of Vitamin D Receptor Dimerization”.
J. Org. Chem. 2000, 65, 8290-8296.
 
(100) Fall Y, Vitale C, Mouriño A.
“An Efficient Synthesis of the 25-Hydroxy Windaus-Grundsmann Ketone”
Tetrahedron Lett. 2000, 41, 7337-7340.
 
(99) Fall Y, Fernández C, Vitale C, Mouriño A.
“Stereoselective Synthesis of Vitamin D3 Analogues with Cyclic Side Chains
Tetrahedron Lett. 2000, 41, 7323-7326.
 
(98) Fernández-Gacio A, Vitale C, Mouriño A.
“Synthesis of New Aromatic (C17–C20)-Locked Side-Chain Analogs of Calcitriol (1,25-Dihydroxyvitamin D3
J. Org. Chem. 2000, 65, 6978-6983.
 
(97) van den Top HP, Boenke A, Burdaspal PA, Bustos J, van Egmond HP, Legarda T, Mesego A, Mouriño A, Paulsch WE, Salgado C.
“The Development of Reference Materials for Paralytic Shellfish Poisoning Toxins in Lyophized Mussel. I: Interlaboratory Studies of Methods of Analysis”.
Food Additives and Contaminants 2000, 17, 419-433.
 
(96) Codesido EM, Cid M, Castedo L, Mouriño A, Granja JR.
“Synthesis of Vitamin D Analogues with a 2-Hydroxy-3-deoxy Ring A”.
Tetrahedrom Lett. 2000, 41, 5861-5864.
 
(95) Pérez-Sestelo J, Mouriño A, Sarandeses LA
"Design and Synthesis of a 1a,25-Dihydroxyvitamin D3 Dimer as a Potential Chemical Inducer of Vitamin D Receptor Dimerization"
Org. Lett. 1999, 1, 1005-1007.
 
(94) Rey MA, Martínez JA, Fernández-Gacio A, Halkes K, Fall Y, Granja J, Mouriño A.
"New Synthetic Strategies to Vitamin D Analogs Modified at the Side Chain and D ring. Synthesis of 1a,25-Dihydroxy-16-ene-vitamin D3 and C-20 Analogs."
J. Org. Chem. 1999, 64, 3196-3206.
 
(93) José Pérez Sestelo, María del Mar Real, Antonio Mouriño, Luis A. Sarandeses
"Synthesis of polycyclic structures by Diels-Alder reaction using inner-outer-ring 1,3-bis[trimethylsilyloxy]dienes"
Tetrahedron Lett. 1999, 40, 985-988.
 
(92) Pérez I, Pérez-Sestelo J, Maestro MA, Mouriño A, Sarandeses LA.
"First Nickel-Catalized 1,4-conjugate Additions to 1,4-Unsaturaded Systems Using Triorganoindium Compounds"
J. Org. Chem. 1998, 63, 10074-10076.
 
(91) Mouriño A, Sestelo JP, Sarandeses L.
"Conjugate additions to electron-deficient olefins. Synthesis of Vitamin D Metabolites and Analogues."
"Synthetic Organic Sonochemistry". Ed.: Jean-Louis Luche
Plenum Press 1998, 363-365.
 
(90) Martínez-Pérez JA, Sarandeses L, Granja J, Palenzuela JA, Mouriño A.
“Design and Synthesis of 1,25-Dihydroxyvitamin D3 Analogues with Fixed Torsion Angle C(16-17-20-22).
Tetrahedron Lett. 1998, 39, 4725-4728.
 
(89) Ana M. García, José L. Mascareñas, Luis Castedo and Antonio Mouriño
“The Alkenyl-Zinc Mediated Approach to the Vitamin D Skeleton. Application to the Synthesis of 6-Methyl Analogs of Vitamin and Previtamin D.
J. Org. Chem. 1997, 62, 6353-6358.
 
(88) Torneiro M, Fall Y, Castedo L, Mouriño A.
“Copper-Mediated Alkylation of Vitamin D C-Ring. Synthesis of C11-Functionalized 1,25-Dihydroxyvitamin D3.”
Tetrahedron 1997, 53, 10851-1087.
 
(87) Torneiro M, Fall Y, Castedo L, Mouriño A.
 "A Short, Efficient Copper-mediated Synthesis of 1a,25-Dihydroxyvitamin D2 (1,25-Dihydroxy-ergocalciferol) and C-24 Analogs".
J. Org. Chem. 1997, 62, 6344-6352.
 
(86) Mouriño A, Torneiro M, Vitale C, Fernández S, Pérez-Sestelo, Anné JS,Gregorio C.
Efficient and Versatile Synthesis of A-Ring Precursors of 1,25-Dihydroxy-vitamin D3 and Analogues. Application to the Synthesis of Lythgoe-Roche Phosphine Oxide.
Tetrahedron Lett. 1997, 38, 4713-4716.
 
(85) Fall, Y.; Torneiro, M.; Castedo, L.; Mouriño, A.
“An Efficient Stereoselective Synthesis of 1,24(R)-Dihydroxyvitamin D3 by the Dienyne Route”.
Tetrahedron  1997, 53, 4703-4714.
 
(84) Massheimer V, Vazquez G, Picotto G, Skliar M, Benassati S, Curino A, Torneiro M, Fall Y, Vitale C, Mouriño A.
"Substitution at the Side Chain of 1,25-(OH)2-D3 Generates Analogs Having Increased Non-Genomic Activity and Target Cell Selectivity than the Animal Hormone 1,25-(OH)2-D3"
Vitamin D: Chemistry, Biology and Clinical Applications of the Steroid Hormone"
Ed.: A.W. Norman, R. Bouillon, M. Thomasset.
University of California Press. Riverside1997, 373-374.
 
(83) Fernández-Gacio A, Breitenbach M, Strasser P, Haussler M, Kungl A, Pittenauer E, Bailer J, Mouriño A, Reischl W.
"Expression and Purification of Recombinant Non-Fusion Human 1,25-(OH)2-D3 Receptor"
Vitamin D: Chemistry, Biology and Clinical Applications of the Steroid Hormone"
Ed.: A.W. Norman, R. Bouillon, M. Thomasset.
University of California Press. Riverside 1997, 226-227.
 
(82) Fall Y, Vitale C, Varela C, Avión J, Mouriño A.
"A Stereoselective Synthessis of 1,24(R),25-Trihydroxy-D22 Vitamin D3"
Vitamin D: Chemistry, Biology and Clinical Applications of the Steroid Hormone"
Ed.: A.W. Norman, R. Bouillon, M. Thomasset.
University of California Press. Riverside 1997, 38-39.
 
(81) Sestelo JP, Sarandeses LA, Maestro M, Fall Y, Torneiro M, Mouriño A.
"A Stereoselective Synthesis of 1,25-Dihydroxy-22-oxavitamin D3"
Vitamin D: Chemistry, Biology and Clinical Applications of the Steroid Hormone"
Ed.: A.W. Norman, R. Bouillon, M. Thomasset.
University of California Press. Riverside 1997, 36-37.
 
(80) Vitale C, Fall Y, García AM, Rey MA, Momán E, Mouriño A.
"A stereoselective Synthesis of Active Vitamin D3 Analogs with Restricted Side Chain Conformation"
Vitamin D: Chemistry, Biology and Clinical Applications of the Steroid Hormone"
Ed.: A.W. Norman, R. Bouillon, M. Thomasset.
University of California Press. Riverside 1997, 34-35.
 
(79) Torneiro M, Gregorio C, Fernández S, Gómez C, Fall Y, Sestelo JP, Sarandeses LA, Cornella I, Mouriño A.
"A Convenient Synthesis of the Lythgoe Vitamin D Ring A Phosphine Oxide"
Vitamin D: Chemistry, Biology and Clinical Applications of the Steroid Hormone"
Ed.: A.W. Norman, R. Bouillon, M. Thomasset.
University of California Press. Riverside 1997, 26-27.
 
(78) García AM, Mascareñas JL, Castedo L, Mouriño A.
"Convergent Synthesis of a 6-Methylvitamin D Derivative Using an Alkenyl-Zinc Mediated Cross-Coupling Reaction"
Vitamin D: Chemistry, Biology and Clinical Applications of the Steroid Hormone"
Ed.: A.W. Norman, R. Bouillon, M. Thomasset.
University of California Press. Riverside 1997, 28-29.
 
(77) Rumbo A, Mouriño A, Castedo L, Mascareñas JL.
"3-Hydroxy-4-pyrones as Precursors of 4-Methoxy-3-oxidopyridinium Ylides. An Expeditious Entry to Highly Substituted 8-Azabicyclo[3.2.1]octanes"
J. Org.Chem. 1996,61, 6114-6120.
 
(76) Vrielinck S, Vandewalle M, García AM, Mascareñas JL, Mouriño A.
“A Chemoenzymatic Synthesis of A-ring Key-intermediates for 1,25-Dihydroxyvitamin D3and Analogues”.
Tetrahedron Lett. 1995, 36, 9023-9026.
 
(75) García AM, Mascareñas JL, Castedo L,Mouriño A.
“A Mild Palladium-Catalysed Convergent Approach to the Vitamin D Skeleton”.
Tetrahedron Lett. 1995, 36, 5413-5416.
 
(74) Allewaert K, Sarandeses LA, Mouriño A, Calverley M, Convents R, Tan KB, Zhao J, Bouillon R.
"Antagonist Activity of 24-Oxa-analogs of Vitamin D"
Steroids 1995, 60, 484-490.
 
(73) Mouriño A, Castedo L, Mascareñas JL, Granja J, Sarandeses L, Maestro M, Torneiro M, Fall Y.
"Panorama actual, Diseño y Síntesis de Análogos y Metabolitos de la Vitamina D"
Vitamina D: De factor nutricional a hormona multifuncional
Ed.: José M. Quesada
Servicio de Publicaciones, Universidad de Córdoba . Córdoba 1994, 109-127.
 
(72) Maestro FJ, Maestro M, Mouriño A, Tojo R.
"Raquitismo secundario a tratamiento anticonvulsionante. Alteraciones de la vitamina D, fotodensidométricas y radiólogicas". Vitamina D: De factor nutricional a hormona multifuncional
Ed.: José M. Quesada. Servicio de Publicaciones, Universidad de Córdoba. Córdoba1994, 75-83.
 
(71) Torneiro M, Vrielynck S, García AM, Mascareñas JL, Castedo L, Mouriño A.
"A New Route to the Vitamin D Triene System"
"Vitamin D. A Pluripotential Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications"
Walter de Gruyter 1994, 39-40.
 
(70) Granja J, Rey M, Martínez JA, Fernández A, Castedo L, Mouriño A.
"Synthesis of 24-Hydroxy-Vitamin D Analogues"
"Vitamin D. A Pluripotential Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications"
Walter de Gruyter 1994, 45-46.
 
(69) Mascareñas JL, García AM, Varela C, Castedo L, Mouriño A.
"A New Route to the Vitamin D Triene System"
"Vitamin D. A Pluripotential Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications"
Walter de Gruyter 1994, 49-50.
 
(68) Maestro M, Sarandeses L, Riveiros R, Castedo L, Mouriño A.
"Studies on the Synthesis of 19-Norprevitamin D3 Analogues"
"Vitamin D. A Pluripotential Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications"
Walter de Gruyter 1994, 51-52.
 
(67) Pérez-Sestelo J, Mascareñas JL, Castedo L, Mouriño A.
"A Short, Flexible Approach to Vitamin D3Analogues with Modified Side Chains"
Tetrahedron Lett. 1994,35,  275-278.
 
(66) Rumbo A, Castedo L, Mouriño A, Mascareñas J.L.
"Temporary Tethering Strategies for [5+2] Pyrone-Alkene Cycloadditions"
J. Org. Chem. 1993,58, 5585-5586.
 
(65) Bouillon R, Sarandeses L, Allewaert K, Zhao I, Mascareñas JL, Mouriño A, Vrielynck S, de Clercq P, Vandewalle M.
"Biological Activity of Dihydroxylated 19-Nor-(Pre)Vitamin D3".
J. Bone Min. Res. 1993, 8, 1009-1015.
 
(64) Nilsson K, Vallés MJ, Castedo L, Mouriño A, Halkes SJ, van de Velde JP
"Synthesis and Biological Evaluation of 18-Substituted Analogs of 1,25-Dihydroxyvitamin D3"
Bioorg. Med. Chem. Lett. 1993, 3, 1855-1858.
 
(63) Sarandeses LA, Vallés MJ, Castedo L, Mouriño A.
"Synthesis of 24-Oxavitamin D3 and 1-Hydroxy-24-Oxavitamin D3"
Tetrahedron 1993, 49, 71-73.
 
(62) Granja JR, Castedo L, Mouriño A.
"Studies on the Opening of Dioxanone and Acetal Templates and Application to the Synthesis of 1,25-Dihydroxyvitamin D2"
J. Org. Chem. 1993, 58, 124-131.
 
(60) Sarandeses LA, Mascareñas JL, Castedo L, Mouriño A.
"Synthesis of 1,25-Dihydroxy-19-norprevitamin D3"
Tetrahedron Lett. 1992, 33, 5445-5448.
 
(59) Mascareñas JL, García A, Castedo L, Mouriño A.
"A Novel Entry to the Vitamin D Triene System"
Tetrahedron Lett. 1992, 33, 7 589-7592.
 
(58) Skliar MI, Boland RL, Mouriño A, Tojo G.
"Isolation and Identification of Vitamin D3, 25-Hydroxyvitamin D3, 1,25-Dihydroxyvitamin D3 and 1,24,25-Trihydroxyvitamin D3 in Solanum Malacoxylon Incubated with Ruminal Fluid"
J. Steroid Biochem. Molec. Biol. 1992, 43, 677-682.
 
(57) Fall Y, Torneiro M, Castedo L, Mouriño A.
"A Nitrile Approach to the Synthesis of the Side Chain of Vitamin D"
Tetrahedron Lett. 1992, 33, 6683-6686.
 
(56) Maestro MA, Castedo L, Mouriño A.
"A Convergent Approach to the Dihydrotachysterol Diene System. Application to the Synthesis of Dihydrotachysterol2 (DHT2), 25-Hydroxydihydrotachysterol2 (25-OH-DHT2), 10(R),19-Dihydro-(5E)-3-epivitamin D2 and 25-Hydroxy-10(R),19-dihydro-(5E)-3-epivitamin D2".
J. Org. Chem. 1992, 57, 5208-5213.
 
(55) Mascareñas JL, García AM, Castedo L, Mouriño A.
"A Short Efficient Route to 1-Hydroxylated Vitamin D Ring A Fragments"
Tetrahedron Lett. 1992, 33, 4365.
 
(54) Seebach D, Mouriño A, Maestro M.
"Structure and Reactivity of Five- and Six-Ring N,N-, N,O-, and O,O-Acetals: A Lesson in Allylic 1,3-Strain (A-1,3 Strain)."
Helv. Chim. Acta 1992, 75, 913-934.
 
(53) Maestro M, Rukhuizen RB, Bosch R, Norman AW, Castedo L, Mouriño A.
"Synthesis and Biogical Activity of the Dihydrotachysterol2 Metabolite 25-Hydroxy-dihydrotachysterol2"
J. Steroid Biochem. Molec. Biol. 1992, 43, 359-361.
  
(52) Fernández B, Martínez-Pérez JA, Granja JR, Castedo L, Mouriño A.
"Synthesis of Hydrindane Derivatives Related to Vitamin D"
J. Org. Chem. 1992, 57, 3173-3178.
 
(51) Sarandeses L, Mouriño A, Luche JL.
"Sonochemistry of Epoxyalkylhalides in the Presence of a Zinc-Copper Couple"
J. Chem. Soc., Chem. Commun.1992, 798-799.
 
(50) Vallés MA, Castedo L, Mouriño A.
"Functionalization of Vitamin D Metabolites at C-18 and Application to the Synthesis of 1,18,25-Trihydroxyvitamin D3 and 18,25-Dihydroxyvitamin D3.
Tetrahedron Lett. 1992, 33, 1503-1506.
 
(49) Torneiro M, Fall Y, Castedo L, Mouriño A.
"An Efficient Route to 1,25-Dihydroxyvitamin D3 Functionalized at C-11"
Tetrahedron Lett. 1992, 33, 105-108.
 
(48) Sarandeses LA, Mouriño A, Luche JL.
“Cleavage of 2,3-Epoxyalkylhalides by the Sonochemical Zinc-Copper Couple”
J. Chem. Soc., Chem. Commun.1991, 818-820.
 
(47) Maestro M, Sardina FJ, Castedo L, Mouriño A.
"Stereoselective Synthesis and Thermal Rearrangement of the First Analogue of (7Z)-Vitamin D"
J. Org. Chem. 1991, 56, 3582-3587.
 
(46) J. Maestro, M. Maestro, M. Babarro, A. Mouriño, J. Espinosa, R. Tojo
"Relationship Between Vitamin D System and Antiepileptic Drugs"
"Vitamin D: Gene Regulation, Structure-Function Analysis and Clinical Application"
Walter de Gruyter 1991, 713.
 
(45)Maestro J, Pavón P, Maestro M, Espinosa J, Mouriño A, Tojo R
"25-OH-Vitamin D and Celiac Disease Activity"
"Vitamin D: Gene Regulation, Structure-Function Analysis and Clinical Application".
Walter de Gruyter, 1991, 554.
 
(44) Pérez-Sestelo J, Fall Y, Mascareñas JL, García A, Mouriño A, Castedo L.
"A Short, Flexible Route to Vitamin D Metabolites and their Side Chain Analogs"
"Vitamin D: Gene Regulation, Structure-Function Analysis and Clinical Application"
Walter de Gruyter 1991, 194-195.
 
(43) Mouriño A, Granja JR, Mascareñas JL, Sarandeses LA, Torneiro M, Maestro M, Fall Y, Castedo L.
"Recent Advances in the Chemistry and Synthesis of Vitamin D Metabolites and Analogues"
"Vitamin D: Gene Regulation, Structure-Function Analysis and Clinical Application".
Walter de Gruyter, 1991, 199-207.
 
(42) Castedo L, Sarandeses L, J. Granja J, Mascareñas JL, Maestro MA, Mouriño A.
"Synthesis of Potential Inhibitors of Vitamin D Hydroxylases"
"Bioorganic Chemistry and Technology"
Plenum Press 1991, 251-253.
 
(41) Mascareñas JL, Pérez-Sestelo J, Castedo L, Mouriño A.
"A Short, Flexible Route to Vitamin D Metabolites and Side Chain Analogues"
Tetrahedron Lett. 1991, 32, 2813-2816.
 
(40) Mascareñas JL, Sarandeses LA, Castedo L, Mouriño A.
"Palladium-Catalysed Coupling of Vinyl Triflates with Enynes and its Application to the Synthesis of 1,25-Dihydroxyvitamin D3"
Tetrahedron 1991, 47, 3485-3489.
 
(39) Castedo L, Domarco MC, Granja J, Maestro FJ, Maestro MA, Mascareñas JL, Méndez JM, Mouriño A, Postigo C, Santiago JJ, Sarandeses L, Tojo R.
"Synthesis of Labeled Side Chains of Vitamin D Metabolites and Analogs"
Vitamin D: Molecular, Cellular and Clinicall Endocrinology"
Walter de Gruyter 1988, 74-75.
 
(38) Rookhuizen R, Bosch R, Castedo L, Cota JG, Granja J, Maestro MA, Martínez-Marigorta E, Mouriño A.
"Synthesis of 25-Hydroxydihydrotachysterol2"
"Vitamin D: Molecular, Cellular and Clinicall Endocrinology
"Walter de Gruyter 1988, 68-69.
 
(37) Castedo L, Granja J, Mouriño A, Pumar MC, Sardina FJ, Mosquera RA, Ríos MA.
"Synthesis of the Unnatural (7Z)-Vitamin D Triene System"
"Vitamin D: Molecular, Cellular and Clinicall Endocrinology
"Walter de Gruyter 1988, 62-63.
 
(36) Mouriño A, Castedo L, Fernández BR, Granja J, Maestro MA, Mascareñas JL, Sarandeses L.
"Chemistry of Vitamin D, its Metabolites and Analogs"
"Vitamin D: Molecular, Cellular and Clinicall Endocrinology"
Walter de Gruyter 1988, 34-42.
 
(35) Arévalo F, Fernández ER, Mouriño A, Castedo L.
"Mixed Organocuprates Derived from Ortho-heterosubstituted ArCu Species. Reactions with Simple 4Unsaturated Ketones"
Chem. Lett. 1988, 745-748.
 
(34) Cota JG, Meilán MC, Mouriño A, Castedo L.
"Hydrotitanation-Protonation of Vitamin D2 and its Analogs, An Efficient Method for the Preparation of 10,19-Dihydrovitamins D2 Including Dihydrotachysterol2"
J. Org. Chem. 1988, 53, 6094-6099.
 
(33) Pumar MC, Mouriño A, Castedo L.
"Estudios en la Síntesis de Metabolitos de la Vitamina D y Análogos. Síntesis del Diacetato de 1,3-Dihidroxi-1-metil-colesta-5,6-dieno
Anal. Quím. 1988, 84C, 100-104.
 
(32) Pumar MC, Mouriño A, Castedo L.
"Estudios en la Síntesis de Metabolitos de la Vitamina D y Análogos. Síntesis de Triacetato de 1,3,5-Trihidroxi-21-nor-colesta-1,7-dieno"
Anal. Quím. 1988, 84C, 105-111.
 
(31) Castedo L, Mascareñas JL, Mouriño A, Sarandeses L.
"Palladium-Catalyzed Synthesis of Dienynes Related to 1,25-Dihydroxyvitamin D3"
Tetrahedron Lett. 1988, 29, 1203-1206.
 
(30) Castedo L, Granja J, Maestro MA, Mouriño A.
"Stereoselective Synthesis of 25-Hydroxyvitamin D2 Side Chain Via the Acetal Template Route"
Tetrahedron Lett. 1987, 28, 4589-4590.
 
(29) Castedo L, Mascareñas JL, Mouriño A.
"An Improved Synthesis of 1,25-Dihydroxyvitamin D A Synthons"
Tetrahedron Lett. 1987, 28, 2099-2102.
 
(28) Hoeger CA, Jonston AD, Okamura WH (Véase contribución de A. Mouriño en notas y agradecimientos, y trabajo publicado en Walter de Gruyter: "Vitamin D....,
1985, 777-787.
J. Am. Chem. Soc. 1987, 109, 4690-4698.
 
(27) Castedo L, Granja JR, Mouriño A, Pumar MC.
"An Efficient Approach to the Unnatural Chirality of Steroid Side Chains at C-20"
Synth. Commun. 1987, 17, 251-256.
 
(26) Castedo L, Mouriño A, Sarandeses L.
"Palladium-Catalyzed Synthesis of Dienynes Related to Vitamin D from Enol Triflates"
Tetrahedron Lett. 1986, 27, 1523-1526.
 
(25) Mascareñas JL, Mouriño A, Castedo L.
Studies on the Synthesis of Side-Chain Hydroxylated Metabolites of Vitamin D. 3. Synthesis of 25-Ketovitamin D3 and 25-Hydroxyvitamin D3"
J. Org. Chem. 1986, 51, 1269-1272.
 
(24) Sardina FJ, Mouriño A, Castedo L.
"Studies on the Synthesis of Side-Chain Hydroxylated Metabolites of Vitamin D. 2. Stereospecific Synthesis of 25-Hydroxyvitamin D2"
J. Org. Chem. 1986, 51, 1264-1268.
 
(23) Hoeger CA. Okamura WH (Véase contribución de A. Mouriño en notas y agradecimientos y trabajo relacionado publicado en Walter de Gruyter, "Vitamin D.....", 1985, 777-787
"On the Antarafacial Stereochemistry of the Thermal [1,7]-Sigmatropic Hydrogen Shift"
J. Am. Chem. Soc. 1985, 107, 268-270.
 
(22) Castedo L, Granja JR, Mouriño A.
"(2,3)-Wittig Sigmatropic Rearrangements in Steroid Synthesis. New Stereocontrolled Approach to Steroidal Side Chains at C-20"
Tetrahedron Lett. 1985, 26, 4959-4960.
 
(21) Okamura WH, Hoeger CA, Johnston AD, Mouriño A.
"Recent Advances in Vitamin D Chemistry: [1,7]-Sigmatropic Hydrogen Shifts and tert-Butyl Substituted Vitamin D Analogues"
"Vitamin D. A Chemical, Biochemical and Clinical Update"
Walter de Gruyter 1985, 777-787.
 
(20) Castedo L, Cota JG, Meilán MC, Mouriño A,Tojo R.
Hydrotitanation-Protonation of Vitamin D2. A Simple Entry to Dihydrovitamin D2"
"Vitamin D. A Chemical, Biochemical and Clinical Update"
Walter de Gruyter 1985, 794-795.
 
(19) Fernández B, Mascareñas JL, Pumar MC, Vila MJ, Mouriño A, Castedo L
"A Simple Entry to 25-Ketoderivatives of Vitamin D. A New Route to Radio-Labelled Vitamin D Metabolites and Analogues"
Vitamin D. A Chemical, Biochemical and Clinical Update"Walter de Gruyter  1985, 792-793.
 
(18) Sardina J, Mouriño A, Castedo L.
"A Stereocontrolled Synthesis Synthesis of 25-Hydroxyvitamin D2"
"Vitamin D. A Chemical, Biochemical and Clinical Update"
Walter de Gruyter 1985, 788-789.
 
(17) F.J. Sardina, A. Mouriño, and L. Castedo
"Studies on the Synthesis of Side Chain Hydroxylated Metabolites of Vitamin D. Stereospecific Synthesis of 25-Hydroxy-7,8-dihydroergosterol and its C-24 Epimer"
Tetrahedron Lett. 1983, 24, 4477-4480.
 
(16) Sardina FJ, Jonston AD, Mouriño A, Okamura WH.
"2-Methyl-5-tert-butylcyclohexane-1,3-dione and Related 2-Alkylcyclohexane-1,3-diones from 1,3-Dimethylbenzenes"
J. Org. Chem. 1982, 47, 1576-1578
 
(15) Tojo R, Pavón P, Antelo J, Mouriño A.
"Vitamin D and its Metabolites. Advances in the Diagnosis and Treatment of Rickets"
Acta Vitaminol. Enzymol. 1982, 4, 1-11.
 
(14) Tojo R, Mouriño A, Antelo J, Paz M.
"Fetomaternal Serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Relationships at Term"
"Vitamin D: Chemical, Biochemical and Clinical Endocrinology of Calcium Metabolism"
Walter de Gruyter 1982, 703-705.
 
(13) Condran P, Hammond ML, Mouriño A, Okamura WH.
"Studies on Vitamin D (Calciferol) and Its Analogues. 18. The Vinylallene Approach to the 1-Hydroxyvitamin D System. New Sigmatropic Reactions in the Vitamin D Series"
J. Am.Chem. Soc. 1980, 102, 6259-6262
 
(12) Mouriño A, Lewicka-Piekut A, Norman AW, Okamura WH.
"Studies on Vitamin D (Calciferol) and Its Analogues. 20. Synthesis of 3-Deoxy-3,3-dimethyl-1-hydroxyvitamin D3 from Vinylallene Intermediates and Related Thermal and Configurational Studies"
J. Org. Chem. 1980, 45, 4015-4020.
 
(11) Okamura WH, Condran P, Hammond ML, A. Mouriño A.
"The Vinylallene Approach to 1-Hydroxyvitamin D Analogs"
"Vitamin D: Basic Research and its Clinical Applications"
Walter de Gruyter 1979, 5-12.
 
(10) Mouriño A, Okamura WH.
"Studies on Vitamin D (Calciferol) and Its Analogues. 14. On The 10,19-Dihydrovitamins Related to Vitamin D2 Including Dihydrotachysterol2".
J. Org. Chem. 1978, 43,  1653-1656.
 
(9) Okamura WH, Mitra MN, Pirio MR, Mouriño A.
"Studies on Vitamin D (Calciferol) and Its Analogues. 13. 3-Deoxy-3-methyl-1a-hydroxyvitamin D3, 3-Deoxy-3-methyl-1,25-dihydroxyvitamin D3, and 1a-Hydroxy-3-epivitamin D3. Analogues with Conformationally Biased A Rings."
J. Org. Chem. 1978, 43, 574-580.
 
(8) Hammond ML, Mouriño A, Okamura WH.
"Sigmatropic Rearrangement of Vinylallenes: A Novel Route to the 1-Hydroxyvitamin D System"
J. Am. Chem. Soc. 1978, 100, 4907-4908.
 
(7) Mouriño A, Blair P, Wecksler W, Jonhson RL, Norman AW, Okamura WH.
"Studies on Vitamin D (Calciferol) and Its Analogues. 15. 24-Nor-1,25-dihydroxyvitamin D3 and 24-Nor-25-hydroxy-5,6-trans-vitamin D3"
J. Med. Chem. 1978, 21, 1025-1029.
 
(6) Mouriño A.
"An Improved Synthesis of 1,3-Dihydroxycholest-5,7-diene"
Synth. Commun. 1978, 8, 127-134.
 
(5) Hammond ML, Mouriño A, P. Blair, Wecksler W, Johnson RL, Norman AW, Okamura WH.
"19-Hydroxy-10S(19)-dihydroxyvitamin D3 and 25-Hydroxy-24-norvitamin D3. Analogs with Anti- metabolite Activity and Related Studies"
"Vitamin D: Biochemical, Chemical and Clinical Aspects Related to Calcium Metabolism"
Walter de Gruyter 1977, 1
 
(4) Okamura WH, Hammond ML, Condran P, Mouriño
 A."Synthesis and Conformational Analysis of Vitamin D Metabolites and Analogs"
"Vitamin D: Biochemical, Chemical and Clinical Aspects Related to Calcium Metabolism”
"Walter de Gruyter 1977, 33-45.
 
(3) Castedo L, Suau R, Mouriño A.
"A Revised Structure for Pontevedrine"
Tetrahedron Lett. 1976, 501-502.
 
(2) Castedo L, Suau R, Mouriño A
"Isoquinoline Alkaloids. IV. A Simple Entry to Oxoaporphine Alkaloids"
Heterocycles 1975, 3, 449-451.
 
(1) Castedo L, Suau R, Mouriño A
"Oxidación Fotosensibilizada de Alcaloides Aporfínicos"
An. Quím. 1975, 73, 290-292.
 
.

  

 

 PATENTS

  

(1) Preparation of 16-dehydrovitamin D derivatives, their intermediates, and pharmaceutical compositions containing them. De Los Angeles, Rey Maria; Mourino, Antonio; Fernandes-Garcio, Anna; Fall, Yagamare; Halkes, Coen M.; Van De Velde, Jan-Paul; Zorgdrager, Jan; Halkes, Sebastianus J. (Duphar International Research B. V., Neth.). Jpn. Kokai Tokkyo Koho (1998), 34 pp. JP 10316652A2 19981202. Application: JP 98-132611 19980428. Priority: EP  97-201334  19970502.

 

 (2) Preparation of Vitamin D analogs. Mourino, Antonio; Martinez, Jose Antonio; De Los Angeles, Rey Maria; Granja, Juan; Halkes, Sebastianus J. (Duphar International Research B.V, Neth.). Eur. Pat. Appl. (1996), 34 pp.  EP 717034A1 19960619. Application: EP 95-203412 19951208. Priority: EP 94-203616  19941214.

 

(3) Vitamin D compounds and method of preparing these compounds. Torneiro, Mercedes; Fall, Yagamare; Mourino, Antonio; Zorgdrager, Jan; Van De Velde, Jan-Paul. (Duphar International Research B.V., Neth.). Eur. Pat. Appl. (1995), 26 pp. EP 664287A1 19950726. Application: E  95-200063  19950112. Priority: EP 94-200131 19940120.

 

(4) Preparation of vitamin D analogs as cell differentiation inducers. Sestelo, Jose P.; Mourino, Antonio; Mascarenas, Jose L.; Halkes, Sebastianus J.; Zorgdrager, Jan; Dijkstra, Gerhardus D. H.; Van, De Velde Jan-paul.  (Duphar International Research B.V., Neth.). Eur. Pat. Appl. (1995), 35 pp.  EP 633245 A1 19950111. Application: EP 94-201403  19940518. Priority: US  93-70998  19930604. 

 

 (5) Regioselective oxidative method of preparing hydrindane compounds and hydrindane-related compounds. Maestro, Miguel A.; Mourino, Antonio; Borsje, Benjamin; Halkes, Sebastianus J.  (Duphar International Research B.V., Neth.). Can. Pat. Appl. (1994), 16 pp. CA 2104418AA  19940225. Application: CA 93-2104418 19930819. Priority: EP 92-202565 19920824.

 

 (6) Preparation of Vitamin D Analogs. Valles, Maria Jose; Mascarenas, Jose Luiz; Mourino, Antonio; Halkes, Sebastianus J.; Zorgdrager, Jan. (Duphar International Research B.V., Neth.). Eur. Pat. Appl. (1993), 40 pp. EP 521550A2 19930107. Application: EP 92-201851 19920624. Priority: EP 91-201746  19910705; EP 92-200154  19920120.

 

 (7) Novel vitamin D derivatives, preparation and uses thereof”. Moras D, Mouriño A, Rodrigues LC, Rochel N, Wurtz JL. Eur. Pat. Appl. (2005) EP n°05 292017.0.  September 29 2005 . CNRS/ Université Louis Pasteur/ Universidad de Santiago de Compostela.

 

 (8) 6-Methylvitamin D3 analogs and their uses. DeLuca H, Sokolowska K, Clagett-Dame M, Plum L, Sicinski R, Mouriño A. 6-Methylvitamin D3 analogs and their uses. WARF Ref. No. P100082US01. US 8,178,517B2. Serial number 61/248126. Wisconsin Alumni Research Foundation Madison  (2009)

 

 (9) Deuterated Vitamin D Compounds. Maestro M, Mouriño A, Nicoletti D, Sigüeiro R. (Universidad de Santiago). Publ Nº WO 2009/156543A1. Publ date: DIC 30, 2009. Application Number: ES2331289B2. Priority: P 2008 01938 (27.06.2008). EP2360154A1, US2011213168A1

 

 (10) Intermedios versátiles y funcionalizados de la vitamina D y nuevos derivados. López-Pérez B, Sigüeiro R, Maestro M, Mouriño A. (Universidad de Santiago). Application Number: ES-396524B2. Priority: P201231923 (11.12.2012).

 

(11) Novel vitamin D receptor modularor with partial agonist activity. Antonio Mouriño et al.  PCT/JP2012055254. Nihon University. Date of filing: 01.03.12. Priority: JP/02.03.11/JPA2011045022

 

(12) Análogos de la vitamina D con interés farmacéutico. Antonio Mouriño, Roman Pérez, Miguel Maestro, Seoane Ruzo, Castelao Fernández, Pranjal Gogoi. P201331689. Fecha: 20 NOV 2013